Clinical Evidence

Cold and hot contrast therapy device information.

Clinically Proven Benefits

After an injury or orthopedic surgery, the rehab and recovery process is critical to successful outcomes. With the Game Ready* GRPro* 2.1 cold and compression therapy system, finish strong and get back to what matters.†

Game Ready OTC Clinical Benefits

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GRPPro 2.1 Clinical Benefits

• May facilitate a decrease in patient opioid consumption and may allow for earlier discontinuation of opioid medications post-operatively.^1,2,3,4,5
• Integrates cold and compression therapies to help reduce pain and edema – outperforming conventional rest, ice, compression, and elevation (RICE) methods.^1,6,7,8
• May increase patient satisfaction with the post-operative recovery process.^1,6,9
• Studies have shown early discharge when using Game Ready.^5,6
• May lead to lower post-operative blood loss.⁷

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Med4 Lite Modality Clinical Benefits

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Cold and Active Compression Therapy

May facilitate a decrease in patient opioid consumption and may allow for earlier discontinuation of opioid medications post-operatively.^1,2,3,4,5

Integrates cold and compression therapies to help reduce pain and edema – outperforming conventional rest, ice, compression, and elevation (RICE) methods.^1,6,7,8

May increase patient satisfaction with the post-operative recovery process.^1,6,9

Studies have shown early discharge when using Game Ready.^5,6

May lead to lower post-operative blood loss.⁷

Heat Therapy

Med4 Elite heat therapy can be used alone or in conjunction with cold for contrast therapy.

Contrast Therapy

The Med4 Elite is capable of a hot-cold changeover rate of less than one minute.

Game Ready Cold Shown in Thermal Imagery

This thermal image shows relative surface temperature after continuous use, comparing GRPro 2.1 to other cold therapy products on the market. Lower surface temperature indicates more effective, more consistent cold delivery throughout treatment.

1. Su EP, Perna M, Boettner F, Mayman DJ, Gerlinger T, Barsoum W, Randolph J, Lee G. A prospective, multi-center, randomised trial to evaluate the efficacy of a cryopneumatic device on total knee arthroplasty recovery. The Journal of Bone and Joint Surgery. 2012; 94-B, Supple A:153-6. https://www.ncbi.nlm.nih.gov/pubmed/23118406.
2. Waterman B, Walker JJ, Swains C, Shortt M, Todd MS, Machen SM, Owens BD. The efficacy of combined cryotherapy compression compared with cryotherapy alone following anterior cruciate ligament reconstruction. The Journal of Knee Surgery. 2012; 25, (02):155-160. https://www.ncbi.nlm.nih.gov/pubmed/22928433.
3. Murgier J, Cassard X. Cryotherapy with dynamic intermittent compression for analgesia after anterior cruciate ligament reconstruction. Preliminary study. Orthopaedics & Traumatology: Surgery & Research. 2014; 100:309-312. https://www.ncbi.nlm.nih.gov/pubmed/24679367.
4. Nabıyev VN, Ayhan S, Adhıkarı P, Cetın E, Palaoglu S, Acaroglu RE. Cryo-compression therapy after elective spinal surgery for pain management: a cross-sectional study with historical control. Neurospine. 2018; 15(4):348-352. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347345/pdf/ns-1836070-035.pdf.
5. Bellon M, Michelet D, Carrara N, Vacher T, Gafsou B, Ilhareborde B, Mazda K, Ferrero E, Simon AL, Julien‑Marsollier F, Dahmani S. Efficacy of the Game Ready* cooling device on postoperative analgesia after scoliosis surgery in children. European Spine Journal. 2019; 28:1257–1264. https://link.springer.com/article/10.1007%2Fs00586-019-05886-6.
6. Klaber I, Greeff E, O’Donnell J. Compressive cryotherapy is superior to cryotherapy alone in reducing pain after hip arthroscopy. Journal of Hip Preservation Surgery. 2019; 0(0):1-6. https://academic.oup.com/jhps/advance-article/doi/10.1093/jhps/hnz048/5610188.
7. Murgier J, Cailliez J, Wargny M, Chiron P, Cavaignac E, Laffosse JM. Cryotherapy with dynamic intermittent compression improves recovery from revision total knee arthroplasty. The Journal of Arthroplasty. 2017; 1-4. https://pubmed.ncbi.nlm.nih.gov/28465126.
8. As with all RICE applications.
9. Leegwater NC, Willems JH, Brohet R, Nolte PA. Cryocompression therapy after elective arthroplasty of the hip. Hip International. 2012; 22 (05):527-533. https://www.ncbi.nlm.nih.gov/pubmed/23112075.

There are inherent risks in all medical devices. Please refer to the product labeling for Indications, Cautions, Warnings and Contraindications. Refer to www.gameready.com for product safety technical bulletins.